Medical Case Reports

Case Report: Suspicion of Amyloidosis Induced Peripheral Neuropathy

39 years old known case of chronic polymyositis and multiple comorbidities, developed new onset progressive sharp pain, numbness and reduced sensation on feet. Symptoms increased in severity and started ascending over one month duration affecting whole both lower limbs. Initial investigation started with Nerve Conduction Study (NCS)/ Electromyography (EMG) testing which showed sensory axonal neuropathy, then a full spectrum lab workup and lumbar magnetic resonance scans were done which didn’t show any acute changes related to the concerning symptoms. Due to amyloidosis query, a buccal biopsy was done and result came back positive for Congo red stain raising the possibility of amyloidosis induced peripheral neuropathy. This case presents the diagnostic path of acute onset peripheral neuropathy in a patient with autoimmune condition, multi-comorbidities and suspicion of amyloidosis.

Author(s): Amer I Zabalawi

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