Medical Case Reports

Durable Response to Letrozole in a Patient with Relapsed Low Grade Endometrial Stromal Sarcoma Metastatic to the Lung - A Case Report

Low Grade Endometrial Stromal Sarcomas (LGESS) are rare uterine neoplasms, with high propensity for local recurrence and an indolent course. Distant metastasis is rare. Hormonal therapy with progestin or aromatase inhibitors has been used successfully to treat relapsed and unresectable disease. We report a 55-year-old female patient with relapsed LGESS in the lungs, who achieved almost complete response to letrozole for more than 6 years. To our knowledge, this is the longest reported durable response with letrozole in patients with LGESS and lung metastasis.

Author(s):

Samer Salah*, Yacob Saleh, Mais Zmaily and Omar Jaber

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