Medical Case Reports

Fertility Preservation in Early Endometrial Cancer in Infertile Patients-Case Series

Background: Endometrial cancer, though often associated with postmenopausal women, affects a notable percentage of premenopausal individuals, with specific risk factors and suitability for conservative management.

Objective: To document incidentally diagnosed early endometrial cancer in infertile women, evaluate their fertility-sparing treatment outcomes, and analyze patient characteristics.

Methods: A retrospective review of cases diagnosed with early endometrial cancer in infertile women was conducted, assessing treatments and outcomes from January 2020 to August 2023.

Results: Among the subjects, the clinical pregnancy rate for endometrial cancer was 0.06%. Most patients (4) were aged 30-40 years, with common comorbidities including diabetes, hypertension, and obesity. The majority (4) were treated at stage FIGO 1A, while a minority necessitated more radical interventions. Three out of five patients positively responded to conservative management with LNG IUD and Tablet medroxyprogesterone acetate for four months, while one required radical hysterectomy due to an advanced cancer stage. One patient remains under surveillance.

Conclusion: Endometrial cancer in infertile women underlines the need for tailored fertility-sparing treatments. Understanding patient demographics, staging and responses to conservative therapies is crucial for effective management and fertility preservation. This study provides insights into the outcomes of such treatments in this specific cohort, emphasizing the importance of personalized care in this context.

Author(s): Nihar Ranjan Bhoi

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