Reconstruction of large size maxillofacial bone defects following trauma or tumor resection still represents a challenging task for surgeons. Various types of bone materials are used as the grafts for the reconstruction of bone defect: auto, allo, xeno and alloplastic bones. In recent years, using the methods of decellularization has enabled to obtain the natural,biocompatible threedimensional xenograft for the reconstruction of bone defects. Removing DNA from the bone matrix is critical because this DNA may stimulate immune reactions by activating cytokine production and B-cell immunoglobulin secretion after transplantation. For the large maxillofacial bone reconstruction procedures, the decellularized bovine bone graft has proven to be effective, easy to handle and biocompatible, providing excellent final aesthetic and functional results. However, more animal and clinical studies are required to further assess the osteogenic activity and integration of decellularized bone grafts with the native bone.
Karalashvili L, Chichua N, Menabde G, Atskvereli L, Grdzelidze T, Machavariani A, Zurmukhtashvili M, Gogilashvili K, Kakabadze Z and Chichua Z
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