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New Frontiers in Vitiligo Treatment: The Low Dose Cytokines-Based Therapy

Skin depigmentation phenomena, caused by the loss of melanocytes, are the distinctive feature of vitiligo. The inner mechanisms of melanocyte loss are still unclear; however, an increasing number of basic and clinical observations highlighted the fundamental role of cellular immunity, chronic inflammatory phenomena and intercellular cross-talk breakdown in vitiligo pathogenesis.

The modulation of inflammatory phenomena and immune response and the restoration of keratinocytes-melanocytes axis with specific low dose SKA interleukins, antibodies and basic fibroblast growth factor represent an innovative therapeutic approach for vitiligo treatment based on Low Dose Medicine paradigm.

Keywords: Vitiligo; Low dose medicine; Inflammation; Sequential kinetic activation; Interleukin 4; Interleukin 10; Anti-interleukin-1 antibodies; Basicfibroblast growth factor


Torello Lotti

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