Lung cancer is becoming the major cause of cancerrelated deaths in human worldwide. Detection of potentially malignant lung nodules is essential for the diagnosis and clinical management of lung cancer. In clinical practice, interpretation of computed tomography (CT) images is challenging for radiologists due to the large number of cases. There are higher rates of false positives in the manual findings. Computer-aided detection (CADe) and computer-aided diagnosis (CADx) systems enhance the radiologists in accurately delineating the lung nodules. It is extremely important task to analyze CADe and CADx for lung nodule detection. Therefore, it is necessary to review the various techniques in different CADe and CADx proposed and implemented by various researchers. This study aims at analyzing the recent application of various concepts in computer science to each stage of CADe and CADx. This review paper is special in its own kind because it analyses the various techniques proposed by different eminent researchers in noise removal, contrast enhancement, thorax removal, lung segmentation, bone suppression, segmentation of trachea, classification of nodule and non-nodule and finally classification of benign and malignant nodules. A comparison of performance of different techniques implemented by various researchers for the classification of nodule and non-nodule has been specified in the paper. The findings of this review paper will definitely prove to be useful to the research community working on automation of lung nodule detection.
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